How to open Excel in safe mode Following are the simple steps to open Microsoft Excel in safe mode: From the keyboard press the “Windows key” + R to open a “Run” box. Then enter “excel.exe/safe” in the Run dialogue box and press OK. Microsoft Excel will then start in safe mode. Run Dialogue Box Open Excel Safe Mode Tags: excel safe mode, open excel safe mode, start excel in safe mode You Might Also Like How to remove compatibility mode in Excel February 21, 2023 How to freeze a row in Excel June 29, 2023 How to lock cells in Excel June 29, 2023